Water → Desvenlafaxine

Participants

Reaction Conditions

Reaction Steps

A mixture of 5.7 g of sodium sulfide hydrate, and 6 mL of 1-methylpyrrolidone was heated to 145° C. under nitrogen, and then 3.5 g of venlafaxine dissolved in 6 mL of 1-methylpyrrolidone was added. The mixture was stirred and heated at 145° C. under nitrogen, approx. 3.5 g of liquid was distilled off. Reaction mixture was heated at 145° C. for 30 hours, then it was cooled and mixed with 70 mL of ethylacetate and 50 mL of water. The mixture was placed into a refrigerator and after 2 hours crystals were filtered and dried to give 2.5 g of desvenlafaxine.

Provenance & Evidence