Venlafaxine → Desvenlafaxine

Participants

Reaction Conditions

Reaction Steps

A mixture of 78.5 g of anhydrous sodium sulfide, and 525 mL of 1-methylpyrrolidone was heated to 145° C. under nitrogen, and then 145 g of venlafaxine was added. The mixture was stirred and heated at 145° C. under nitrogen for 30 hours, then it was cooled and mixed with 2.9 L of ethylacetate and 2.0 L of water. The mixture was kept in the refrigerator overnight, crystals were filtered and dried to give 106.5 g of desvenlafaxine. Yield 77%.

Provenance & Evidence