HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 1-Benzyl-3-methyl-piperidin-4-one oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 1-Benzyl-3-methyl-4-piperidone | HCID 560965 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Benzyl-3-methyl-piperidin-4-one oxime | HCID 73415325 | — |
Reaction Steps
To a solution of 1-benzyl-3-methyl-piperidin-4-one (2.04 g, 10 mmol) in EtOH (20 mL), was added pyridine (20 mL, 0.25 mol) and hydroxylamine hydrochloride (0.70 g, 10 mmol). After being stirred at 90+ C. overnight, the resultant solution was concentrated in vacuo to give the crude product 1-benzyl-3-methyl-piperidin-4-one oxime. LC/MS m/z: 219 (M+H)+. This material was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491827B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-a68331378fc047c19a9cff0ff75b5a09 |
| Source note | uspto-grants-2009_02 |