HCID 21069821, compound → HCID 21069990, compound

HRID 1726619Notes

Reaction equation

HRID 1726619 reaction equation
[CH2:1]([O:8][C:9]1[C:18](=[O:19])[N:17]2[C:12]([C:13]([CH3:21])([CH3:20])[O:14][CH2:15][CH2:16]2)=[N:11][C:10]=1[C:22]([OH:24])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:25][CH2:26][C:27]1[CH:38]=[CH:37][C:36]([F:39])=[CH:35][C:28]=1[C:29]([NH:31][CH:32]1[CH2:34][CH2:33]1)=[O:30]>>[CH:32]1([NH:31][C:29]([C:28]2[CH:35]=[C:36]([F:39])[CH:37]=[CH:38][C:27]=2[CH2:26][NH:25][C:22]([C:10]2[N:11]=[C:12]3[N:17]([C:18](=[O:19])[C:9]=2[O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:16][CH2:15][O:14][C:13]3([CH3:20])[CH3:21])=[O:24])=[O:30])[CH2:33][CH2:34]1

Participants

3

Reactant 2

HCID 21069821HCID 21069821, compoundHCID 210698583-(Benzyloxy)-9,9-dimethyl-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carboxylic acid

Product 1

HCID 21069990HCID 21069990, compound

Procedure

The title compound can be prepared from intermediate 27, 3-(benzyloxy)-9,9-dimethyl-4-oxo-4,6,7,9-tetrahydropyrimido-[2,1-c][1,4]oxazine-2-carboxylic acid and intermediate 40, 2-(aminomethyl)-N-cyclopropyl-5-fluorobenzamide. LC/MS m/z 521 (M+H).

Sources & evidence

ORD record
ord-c6789766c40c4c709a43ba8299fae066
Source dataset
uspto-grants-2009_02
Patent number
US07491819B1

Reaction notes

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