HCID 58777355, compound → HCID 54717460, compound

Participants

Reaction Steps

The title compound can be prepared by hydrogenolysis (H2, 10% Pd—C) of intermediate 195, (R)—N-(2-(2-(azidomethyl)-5-oxopyrrolidin-1-yl)-4-fluorobenzyl)-3-(benzyloxy)-9,9-dimethyl-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carboxamide. 1H NMR (400 MHz, MeOD) δ ppm: 7.54 (1H, dd, J=7.0 Hz), 7.25-7.13 (2H, m), 4.62 (2H, m), 4.17 (1H, d, J=15.6 Hz), 4.07 (2H, m), 3.99 (2H, m,), 3.23 (2H, d, J=3.1 Hz), 2.79-2.59 (3H, m), 2.14 (1H, m), 1.66 (6H, s). HRMS calcd for C22H27N5O5F: 460.1996; found 460.2014.

Provenance & Evidence