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HRID1726707

反应详情

EQUATION

反应方程式

HRID 1726707 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)[C@H]1CC(F)(F)CN(C(=O)OCc2ccccc2)[C@@H]1C(=O)OCc1ccccc1
HCID86621497

未命名化合物

结构：[H][H]
HCID178418361

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)[C@H]1CC(F)(F)CN[C@@H]1C(=O)O
HCID67304512

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of 1,2-dibenzyl 3-tert-butyl(2S,3S)-5,5-difluoropiperidine-1,2,3-tricarboxylate (0.370 g, 0.000756 mol) in EtOH (7.0 mL) was hydrogenated in the presence of 10% Pd/C, under a ballon pressure of hydrogen, for 2 h. After filtered off the catalyst, the filtration was evaporated to dry. The residue was used directly in next step (190 mg, 94.77%). LC MS (M-Bu+1) 210.0.

WORKUP

后处理

  1. filtrationAfter filtered off the catalyst
  2. filtrationthe filtration
  3. customwas evaporated
  4. customto dry