反应详情

A mixture of 2-chloro-4-[1-oxo-3-(3-hydroxyphenyl)propyl]benzoic acid, methyl ester (Example 19; 2.1 g, 6.6 mmol) and 1 M sodium hydroxide solution was stirred for 4 h at room temperature. The solution was filtered through Celite and the filter cake was washed with water (5 mL). 1 M HCl (22 mL) was added to the stirred filtrate and the resulting mixture was stirred for 2 h and then filtered. The solid was washed with water, dried and recrystallized from ether/hexane to give 2-chloro-4-[1-oxo-3-(3-hydroxyphenyl)propyl]benzoic acid (1.59 g, 79%) as an off-white solid.

1. filtrationThe solution was filtered through Celite
2. washthe filter cake was washed with water (5 mL)
3. addition1 M HCl (22 mL) was added to the stirred filtrate
4. stirringthe resulting mixture was stirred for 2 h
5. filtrationfiltered
6. washThe solid was washed with water
7. customdried
8. customrecrystallized from ether/hexane