6-Benzyloxy-1-hexanol → 6-Benzyloxyhexanal

HRID 1726824ノート

反応式

HRID 1726824 の反応式
C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O.[CH2:12]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][OH:26])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(Cl)Cl>[CH2:12]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]=[O:26])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 27847636-Benzyloxy-1-hexanolHCID 178418287HCID 178418287、化合物

生成物 1

HCID 3898776-Benzyloxyhexanal

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Synthesis of [18F]-FCPHA was performed using the following method. PCC (pyridinium chlorochromate; 24.8 g, 115.2 mmol) was slowly added in portions to a solution of 6-benzyloxy-1-hexanol (20 g, 96 mmol) in 200 ml of methylene chloride at room temperature (25° C., RT). The black mixture was stirred for 2 hours, and filtered through 50 g of silica gel. The solvent was removed and the crude oil was separated chromatographically on silica gel using a mixture of hexane:ethyl acetate at a ratio of 90:10. This yielded the aldehyde equivalent, 6-benzyloxy-1-hexanal, at a scale of 14 g (70%).

後処理

  1. filtrationfiltered through 50 g of silica gel
  2. customThe solvent was removed
  3. customthe crude oil was separated chromatographically on silica gel using
  4. additiona mixture of hexane

出典と根拠

ORDレコード
ord-ae19c2757ead4d398b256f756ed62c88
出典データセット
uspto-grants-2009_02
特許番号
US07494642B2

反応ノート

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