Water → HCID 21100066, compound

N-(2-trimethylsilylethoxycarbonyl)-N,N′-dimethylethylenediamine was prepared as follows: to a stirred solution of N,N′-dimethylethylenediamine (616 mg, 5.94 mmol) and aqueous sodium carbonate (2M, 25 mL) at room temperature was added a solution of 2-(trimethylsilyl)ethyl-4-nitrophenyl carbonate (1.31 g, 4.63 mmol) in ethanol (15 mL). The reaction was heated at reflux for 1 h and then stirred at room temperature for 20 hours. The suspension was partially reduced in vacuo and the resulting slurry was added to water (100 mL) and extracted with methylene chloride (3×50 mL). The combined organics were filtered, dried over sodium sulfate and reduced in vacuo. The crude residue was purified via MPLC (silica gel, gradient 5-30%, methanol in methylene chloride) to yield N-(2-trimethylsilylethoxycarbonyl)-N,N′-dimethylethylenediamine as a light yellow solid (380 mg, 1.64 mmol, 35% yield); 1H NMR (CDCl3, 300 MHz): δ 4.14 (m, 2H), 3.34 (m, 2H), 2.88 (s, 3H), 2.71 (m, 2H), 2.42 (s, 3H), 0.97 (m, 2H), 0.01 (s, 9H); ESI (+) MS: 233 (M+H+); TLC: Rf=0.06 (4:1, methylene chloride:methanol, Whatman MK6F, 60 angstrom).

1. customN-(2-trimethylsilylethoxycarbonyl)-N,N′-dimethylethylenediamine was prepared
2. temperatureThe reaction was heated
3. temperatureat reflux for 1 h
4. extractionextracted with methylene chloride (3×50 mL)
5. filtrationThe combined organics were filtered
6. dry with materialdried over sodium sulfate
7. customThe crude residue was purified via MPLC (silica gel, gradient 5-30%, methanol in methylene chloride)

ORD record

ord-a2d1e99ad18f4fe280c14e5ab0dc7846

Source dataset

uspto-grants-2009_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07494991B2