4-Iodobenzenesulfonyl chloride → tert-Butyl 4-(3-bromobenzene-1-sulfonyl)piperazine-1-carboxylate

HRID 1726883Notes

Reaction equation

HRID 1726883 reaction equation
N1CCOCC1.[N:7]1([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.IC1C=CC(S(Cl)(=O)=O)=CC=1.[Br:31][C:32]1[CH:33]=[C:34]([S:38](Cl)(=[O:40])=[O:39])[CH:35]=[CH:36][CH:37]=1>>[Br:31][C:32]1[CH:33]=[C:34]([S:38]([N:10]2[CH2:11][CH2:12][N:7]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:8][CH2:9]2)(=[O:40])=[O:39])[CH:35]=[CH:36][CH:37]=1

Participants

5

Reactant 4

HCID 73994-Iodobenzenesulfonyl chlorideHCID 8083MorpholineHCID 17943m-Bromobenzenesulphonyl chlorideHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 45588490tert-Butyl 4-(3-bromobenzene-1-sulfonyl)piperazine-1-carboxylate

Procedure

Identical procedure to Step A of Example 1, but the morpholine is replaced by tert-butyl piperazine-1-carboxylate and the 4-iodobenzenesulphonyl chloride by 3-bromobenzenesulphonyl chloride.

Sources & evidence

ORD record
ord-bcacc85718c347579340f182dd7e58a5
Source dataset
uspto-grants-2009_02
Patent number
US07494994B2

Reaction notes

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