Cyanogen Bromide → HCID 69026805, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-isopropylethylenediamine (10.0 g, 0.097 mol) in methanol (10 ml) was cooled to 0° C. and treated dropwise with a solution of cyanogen bromide (10.37 g, 0.098 mol) in methanol (25 ml) while maintaining the temperature below 10° C. The reaction mixture was then heated to 80° C. for 45 min, cooled and concentrated under reduced pressure. Crystallization of the residue from cold ethanol gave 10.4 g (50% yield) of the title product as white crystals; mp 154-155° C. 1HNMR 400 MHz (CDCl3) δ (ppm): 1.27 (6H, d, J=6.6 Hz, 2×CH3), 3.57-3.75 (4H, m, 2×CH2), 4.41 (1H, m, CH).

Provenance & Evidence