反应详情

Bis(triphenylphosphine)palladium(II) chloride (0.5 mg, 0.72 μmol) was added to a benzene (1.0 ml) solution of 7-bromo-2-tert-butyl-6-iodo-5-methyl-1,3-benzoxazole-4-carbonitrile (I-8) (30 mg, 71.6 μmol), (2-tri-n-butylstannyl)furan (23.7 μl, 75.2 μmol), followed by refluxing overnight. After cooling, water (30 ml) was added, the product was extracted with ethyl acetate (30 ml×2), the organic layer was washed with saturated brine (30 ml), then dried over anhydrous magnesium sulfate, concentrated under reduced pressure. The residue was purified by silica gel column chromatography (h-hexane:ethyl acetate=8:1) to obtain the entitled compound (19 mg) as a colorless solid.

1. temperatureby refluxing overnight
2. temperatureAfter cooling
3. extractionthe product was extracted with ethyl acetate (30 ml×2)
4. washthe organic layer was washed with saturated brine (30 ml)
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe residue was purified by silica gel column chromatography (h-hexane:ethyl acetate=8:1)