2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 68961219, compound

Participants

Reaction Steps

A mixture of 0.51 g of 1-(2,2,2-trifluoroethyl)-3-phenyl-4,5-dihydro-1,2,4-triazin-6-one (2.0 mmol) and 0.48 g of DDQ (2.1 mmol) in 20 mL of ethyl acetate was stirred at room temperature overnight, then heated to 70° C. for 2 hours. The reaction mixture was cooled and washed with aqueous potassium carbonate, water (2 times) and brine, dried over magnesium sulfate, filtered and stripped. The product was dissolved in ethyl acetate/methylene chloride and treated with silica gel, then filtered through silica gel over Celite to give 0.40 g of 1-(2,2,2-trifluoroethyl)-3-phenyl-1,2,4-triazin-6-one, melting point 129-131° C.

Provenance & Evidence