反应详情

3.33 g (12.8 mmol) of 4-hydroxy-naphthalen-1-yl-carbamic acid tert-butyl ester was dissolved in 60 ml of acetone and treated at 0° C. subsequently with 4.60 g (1.1 eq.) of cesium carbonate, 0.107 g (0.05 eq.) of KI, and 1.42 ml (1.0 eq.) of ethyl bromoacetate. After vigorous stirring for 1 h at ambient temperature, the solvent was evaporated and the residue redissolved in AcOEt. Washing with water, drying over magnesium sulfate, and evaporation of the solvents, followed by flash chromatography (SiO2, hexane/AcOEt=75/25), yielded 4.28 g of the title product as off-white crystals.

1. customthe solvent was evaporated
2. dissolutionthe residue redissolved in AcOEt
3. washWashing with water
4. dry with materialdrying over magnesium sulfate, and evaporation of the solvents