反应详情

0.472 g (1.68 mmol) of the above prepared [rac]-1-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol was dissolved in 8 ml of CH2Cl2 and treated dropwise at 0° C. with 0.399 ml (2 eq.) of SOCl2. The reaction mixture was kept at 0° for 5 Min. and at RT for 30 Min. Pouring onto crashed ice/NaHCO3, twofold extraction with AcOEt, washing with water, drying over sodium sulfate, and evaporation of the solvents yielded 0.488 g of pure title compound as light yellow oil.

1. customwas kept at 0° for 5 Min
2. customat RT
3. additionPouring
4. extractionice/NaHCO3, twofold extraction with AcOEt
5. washwashing with water
6. dry with materialdrying over sodium sulfate, and evaporation of the solvents