Triphenylphosphine → HCID 69036617, compound

Participants

Reaction Conditions

Reaction Steps

0.26 g (1.0 mmol) of the above prepared [rac]-3-(4-hydroxy-naphthalen-2-yl)-2-methoxy-propionic acid methyl ester, 0.30 g (1.05 mmol) of 2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol (see below example 4K]) and 0.31 g (1.20 mmol) of triphenylphosphine were dissolved in 10 ml of THF. The stirred reaction mixture was cooled down to 0° C. and a solution of 0.27 g (1.15 mmol) of di-tert.-butyl azodicarboxylate in 5 ml of THF was added drop by drop and the reaction warmed up to ambient temperature. After 20 hours, the solvent was evaporated and the residue purified by chromatography (SiO2, heptane/EtOAc=9:1 to 1:1) to give 0.45 g of the title compound as light yellow oil.

Provenance & Evidence