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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1726988Generated: November 3, 2026

(E)-3-(4-Benzyloxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-acrylic Acid Ethyl Ester → 3-(4-Hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-propionic Acid Ethyl Ester

https://huagongshe.com/reaction/1726988

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(E)-3-(4-Benzyloxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-acrylic Acid Ethyl EsterHCID 69035743—
CatalystPalladiumHCID 23938—
SolventTetrahydrofuranHCID 8028—
Product3-(4-Hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-propionic Acid Ethyl EsterHCID 58566475—

Reaction Steps

1.15 g (3.41 mmol) of the above prepared (E)-3-(4-benzyloxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-acrylic acid ethyl ester was dissolved in 20 ml of tetrahydrofuran and hydrogenated over 0.3 g of 10% of palladium on charcoal as catalyst at ambient temperature and atmospheric pressure. Filtering off the catalyst and evaporating the solvent yielded 0.84 g of the title compound as grey solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07495001B2
Source datasetuspto-grants-2009_02
ORD IDord-2d872f6d990741db974a8eab93086a14
Source noteuspto-grants-2009_02