HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol → 3-(4-{2-[2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-naphthalen-1-yl)-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol | HCID 21935831 | — |
| Reactant | Ethyl 3-(4-hydroxynaphthalen-1-yl)propanoate | HCID 58566550 | — |
| Product | 3-(4-{2-[2-Methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-naphthalen-1-yl)-propionic acid ethyl ester | HCID 69041563 | — |
Reaction Steps
In analogy to the procedures described in example 4D] and 4E], 3-(4-hydroxy-naphthalen-1-yl)-propionic acid ethyl ester [Helvetica Chimica Acta (2001), 84(8), 2198-2211] was reacted with 2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethanol (example 4K]) to give 3-(4-{2-[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-ethoxy}-naphthalen-1-yl)-propionic acid ethyl ester, which was subsequently saponified to yield the title compound as colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07495001B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-e12fdb28a89c43ed9d828378da084d39 |
| Source note | uspto-grants-2009_02 |