HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromomethyl-5-(4-trifluoromethyl-phenyl)-pyrimidine → 3-{4-[5-(4-Trifluoromethyl-phenyl)-pyrimidin-2-ylmethoxy]-naphthalen-1-yl}-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromomethyl-5-(4-trifluoromethyl-phenyl)-pyrimidine | HCID 21935922 | — |
| Reactant | Ethyl 3-(4-hydroxynaphthalen-1-yl)propanoate | HCID 58566550 | — |
| Product | 3-{4-[5-(4-Trifluoromethyl-phenyl)-pyrimidin-2-ylmethoxy]-naphthalen-1-yl}-propionic acid ethyl ester | HCID 69037364 | — |
Reaction Steps
A] In analogy to the procedures described in example 5C] and 5D], 3-(4-hydroxy-naphthalen-1-yl)-propionic acid ethyl ester [Helvetica Chimica Acta (2001), 84(8), 2198-2211] was reacted with 2-bromomethyl-5-(4-trifluoromethyl-phenyl)-pyrimidine (example 11C]) to give 3-{4-[5-(4-trifluoromethyl-phenyl)-pyrimidin-2-ylmethoxy]-naphthalen-1-yl}-propionic acid ethyl ester, which was subsequently saponified to yield the title compound as colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07495001B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-d1af9ac3037e43ce98d24b95c0b83258 |
| Source note | uspto-grants-2009_02 |