反应详情

A mixture of 2 g (8 mmol) of 4-benzyloxy-naphthalen-1-ol [Journal of Medicinal Chemistry (1985), 28(6), 822-41, of 2.67 g (16 mmol) of ethyl bromoacetate and of 3.12 g (9.6 mmol) of cesium carbonate in 30 ml of acetonitrile was stirred at 60° C. for 3 hours. Subsequently, the reaction mixture was evaporated to dryness and the residue was partitioned between water and tert.-butyl methyl ether. The organic phase was separated, washed with water and brine, dried over anhydrous sodium sulfate and finally evaporated. 2.23 g of the title compound were obtained as white crystals after crystallization from n-heptane.

1. customSubsequently, the reaction mixture was evaporated to dryness
2. customthe residue was partitioned between water and tert.-butyl methyl ether
3. customThe organic phase was separated
4. washwashed with water and brine
5. dry with materialdried over anhydrous sodium sulfate
6. customfinally evaporated