Trifluoroacetic acid → HCID 57565640, compound

Participants

Reaction Steps

A solution of tert-butyl [7-(2-chloro-6-fluorobenzyl)-1-ethyl-2,6-dioxo-8-piperidin-1-yl-1,2,6,7-tetrahydro-3H-purin-3-yl]acetate (24 mg, 0.046 mmol) in 230 μL CH2Cl2 was treated with 230 μL TFA. The reaction was stirred at room temperature for 1 hr and then the solvent was removed by reduced pressure. The crude product was filtered through a silica plug and rinsed with 20% MeOH/EtOAc. The solvent was removed affording the title compound (19 mg, 90% yield) as a white solid: 1H NMR (CDCl3, 400 MHz) 7.22-7.16 (m, 1H), 7.14-7.10 (m, 1H), 6.98-6.91 (m, 1H), 5.51 (s, 2H), 4.80 (s, 2H), 3.95 (q, 2H, J=7.0 Hz), 3.11-3.01 (m, 4H), 1.54-1.41 (m, 6H), 1.12 (t, 3H, J=7.0 Hz); MS (ESP+) m/e 464 (MH+).

Provenance & Evidence