Methanol → HCID 23692097, compound

HRID 1727100Notes

Reaction equation

HRID 1727100 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][C:14]([CH2:18][S:19][C:20]3[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][CH:21]=3)([OH:17])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1)#[N:2].CO.[OH-].[Na+:33]>O>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][C:14]([CH2:18][S:19][C:20]3[CH:21]=[CH:22][C:23]([C:24]([O-:26])=[O:25])=[CH:28][CH:29]=3)([OH:17])[CH2:15][CH2:16]2)=[CH:7][CH:8]=1)#[N:2].[Na+:33]

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 23085060HCID 23085060, compound

Product 1

HCID 23692097HCID 23692097, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The compound (248 mg) obtained in Example 42 was suspended in a 50% mixture of methanol and water (10 mL) and was further mixed with 2 N sodium hydroxide solution (0.3 mL), followed by heating under reflux for ten hours. The solvent was removed under reduced pressure, and the residue was crystallized from ethyl acetate. The crystals were collected by filtration, and dried to yield the titled compound (200 mg) as crystals.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for ten hours
  3. customThe solvent was removed under reduced pressure
  4. customthe residue was crystallized from ethyl acetate
  5. filtrationThe crystals were collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-96dee00928d545cda5ee2d218c28e1cd
Source dataset
uspto-grants-2009_02
Patent number
US07494987B2

Reaction notes

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