Sodium Hydroxide → HCID 23692096, compound

HRID 1727103Notes

Reaction equation

HRID 1727103 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][C:14]([CH2:18][S:19]([C:22]3[CH:31]=[CH:30][C:25]([C:26]([O:28]C)=[O:27])=[CH:24][CH:23]=3)(=[O:21])=[O:20])([OH:17])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1)#[N:2].[OH-].[Na+:33]>CO>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][C:14]([CH2:18][S:19]([C:22]3[CH:23]=[CH:24][C:25]([C:26]([O-:28])=[O:27])=[CH:30][CH:31]=3)(=[O:21])=[O:20])([OH:17])[CH2:15][CH2:16]2)=[CH:7][CH:8]=1)#[N:2].[Na+:33]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23085081HCID 23085081, compound

Product 1

HCID 23692096HCID 23692096, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the compound (70 mg) obtained in Example 46 in methanol (2.0 mL) was added 2 N aqueous sodium hydroxide solution (0.080 mL), followed by stirring at room temperature for three days. The solvent was removed under reduced pressure, the residue was mixed with ethyl acetate (4 mL) and was stirred for one hour. Insoluble matter was collected by filtration, and dried to yield the titled compound (56 mg) as crystals.

Workup

  1. customThe solvent was removed under reduced pressure
  2. additionthe residue was mixed with ethyl acetate (4 mL)
  3. stirringwas stirred for one hour
  4. filtrationInsoluble matter was collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-973b7b9a31194f44852e8df9336d55af
Source dataset
uspto-grants-2009_02
Patent number
US07494987B2

Reaction notes

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