Potassium Carbonate → HCID 57566680, compound

Participants

Reaction Steps

To a solution of (Ph3P)4Pd (36 mg, 0.03 mmol) in dioxane ( 4 mL) under Argon was added 6-(2-Fluoro-phenoxy)-3-iodo-indazole-1-carboxylic acid tert-butyl ester (140 mg, 0.3 mmol) and the solution was stirred for 10 min, then 2-chlorophenyl boronic acid (96.4 mg, 0.6 mmol) in ethanol (1.2 mL) was added. After 10 min potassium carbonate (132 mg, 0.9 mmol) in water (0.4 mL) was added and the mixture was stirred at 85° C. under Argon for 18 h. The mixture was cooled to room temperature, filtered through Celite, partitioned between water and EtOAc, the separated organic phase was dried over Na2SO4 filtered, concentrated and the residue was purified by flash chromatography eluting with Hex:EtOAc 9:1 to yield 90 mg of 3-(2-Chloro-phenyl)-6-(2-fluoro-phenoxy)-indazole-1-carboxylic acid tert-butyl ester: MS: 345 (M+H).

Provenance & Evidence