Sodium Methoxide → HCID 11772121, compound

Participants

Reaction Steps

A solution of 3-(2-Chloro-phenyl)-6-(2-fluoro-phenoxy)-indazole-1-carboxylic acid tert-butyl ester (90 mg, 0.2 mmol) and sodium methoxide (22 mg, 0.41 mmol) in methanol (2 mL) was stirred at room temperature for 1 h, and then concentrated under vacuum. The residue was diluted with EtOAc, washed with water, dried over Na2SO4 filtered, concentrated and the residue was purified by flash chromatography eluting with Hex:EtOAc 4:1 to yield 42 mg of 3-(2-Chloro-phenyl)-6-(2-fluoro-phenoxy)-1H-indazole: MS (M+H)+=339

Provenance & Evidence