HCID 57566815, compound → 1-(3-Aminophenyl)-4-(3-benzyloxy-4-methoxyphenyl)-pyrrolidin-2-one

HRID 1727146Notes

Reaction equation

HRID 1727146 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:17]2[CH2:21][N:20]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([N+:28]([O-])=O)[CH:23]=3)[C:19](=[O:31])[CH2:18]2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOC(C)=O.CCO.[Ni]>[NH2:28][C:24]1[CH:23]=[C:22]([N:20]2[CH2:21][CH:17]([C:11]3[CH:12]=[CH:13][C:14]([O:15][CH3:16])=[C:9]([O:8][CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH:10]=3)[CH2:18][C:19]2=[O:31])[CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 1

HCID 57566815HCID 57566815, compound

Product 1

HCID 99775741-(3-Aminophenyl)-4-(3-benzyloxy-4-methoxyphenyl)-pyrrolidin-2-one

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 21584252Ethanol ethylacetateSolvent

Procedure

To a solution of 4-(3-benzyloxy-4-methoxyphenyl)-1-(3-nitrophenyl)-pyrrolidin-2-one (100 mg) in EtOAc/EtOH (2 mL, 1:1) was added Raney Ni. The mixture was then put under vacuum and recharged with H2. The mixture was stirred under H2 for 10 h. After filtration, concentration gave crude product.

Workup

  1. filtrationAfter filtration, concentration
  2. customgave crude product

Sources & evidence

ORD record
ord-4bf2d4e2f3954e51adf179e87972beb9
Source dataset
uspto-grants-2009_02
Patent number
US07495016B2

Reaction notes

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