3-(3-Benzyloxyphenyl)-4-nitrobutyric acid ethyl ester → 4-[3-(Benzyloxy)phenyl]pyrrolidin-2-one

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Reaction Steps

A mixture of 3-(3-benzyloxyphenyl)-4-nitrobutyric acid ethyl ester (3.2 g) in 10 mL EtOAc and 20 mL EtOH was created in a dry round bottom flask. Raney Ni was added and the resulting mixture was stirred under H2 for 10 h at r.t. and filtered through celite. The solution was heated under reflux for 40 h, cooled to r.t., and concentrated. Chromatography of the residue on silica gel (EtOAc:Hexane=1:1 to 3:1) gave 1.89 g of the desired product.

Provenance & Evidence