Trimethylamine → HCID 57566938, compound

Participants

Reaction Steps

3-[4-(2-Hydroxy-4-methoxyphenyl)-2-oxo-pyrrolidin-1-yl]benzamide (32 mg, 0.1 mmol), 3-chlorobenzeneboronic acid (19 mg, 1.2 eq), and copper acetate (1 eq) were added to a dry tube. The mixture was charged with 2 mL CH2Cl2, (CH3)3N (3 eq) followed by addition of 4 Å MS. The mixture was stirred for 24 h and diluted with 10 mL CH2Cl2. After filtration, the mixture was washed with NH4Cl, water, and brine, and then dried. After concentration, the residue was purified by preparative LC-MS to give 7.8 mg of the desired product. Yield: 18%.

Provenance & Evidence