反应详情

温度

125 °C

3-Chloro-2,5-dimethylpyrazine (1.0 g, 7.0 mmol) and N-benzylpiperazine (3.7 ml, 21.0 mmol) were mixed under nitrogen and heated to 125° C. for 18 h. Saturated aqueous sodium hydrogen carbonate was added and the product was extracted with chloroform. The combined organic extracts were dried (Na2SO4) and concentrated in vacuo to give a yellow oil. The crude product was purified by flash chromatography using silica gel eluting with methanol:chloroform (2.5:97.5) to give the pure product as a yellow oil (1.14 g, 58%).

1. extractionthe product was extracted with chloroform
2. dry with materialThe combined organic extracts were dried (Na2SO4)
3. concentrationconcentrated in vacuo
4. customto give a yellow oil
5. customThe crude product was purified by flash chromatography