Hydrochloric Acid → HCID 69059439, compound

Participants

Reaction Steps

A solution of 2-methyl-7-(phenylmethyl)-4-piperidin-1-yl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine (Preparation 88, 12 g) in ethanol (200 ml) was adjusted to pH 2 with concentrated hydrochloric acid, palladium (5% on carbon) was added and the reaction mixture was hydrogenated at 60 psi. The reaction mixture was filtered, and the filtrate concentrated in vacuo. Chloroform and sodium hydroxide (2 M solution) were added and the organic extracts were dried, and concentrated in vacuo. The crude residue was dissolved in petroleum ether (30-40) and cooled in ice, the title compound was collected as a solid.

Provenance & Evidence