HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetamidine monohydrochloride → HCID 69054342, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetamidine monohydrochloride | HCID 67170 | — |
| Reactant | Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride | HCID 2723880 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 69054342 | HCID 69054342 | 93.3% |
Reaction Steps
Sodium metal (4.4 g, 0.19 mol) was dissolved in ethanol (300 ml) and acetamidine hydrochloride (9.3 g, 0.1 mol) was added. After 30 min, commercially available ethyl 3-oxo-1-(phenylmethyl)-piperidine-4-carboxylate hydrochloride (25 g, 0.084 mol) was added and the reaction mixture was refluxed for 18 h. The reaction mixture was filtered and the concentrated in vacuo to give the title compound (20 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07494992B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-2ea8aea4e9274d678885d9806ebbf30e |
| Source note | uspto-grants-2009_02 |