反应详情

1-acetyl-4-{[(4-chlorophenyl)methyl]oxy}piperidine (Preparation 99, 11 g, 41.1 mmol) in methanol (50 ml) and sodium hydroxide solution (5 M, 30 ml) were refluxed on a steam bath for 10 h. After cooling, methanol was removed and the remaining solution was extracted with petroleum ether (40-60, 3×30 ml). The organic extracts were dried (Na2SO4) and concentrated in vacuo to give an white solid (5.8 g, 62%). A portion was recrystallised from petroleum ether to give needle crystals (3 g).

1. temperatureAfter cooling
2. custommethanol was removed
3. extractionthe remaining solution was extracted with petroleum ether (40-60, 3×30 ml)
4. dry with materialThe organic extracts were dried (Na2SO4)
5. concentrationconcentrated in vacuo