Sodium Hydroxide → HCID 69055012, compound

Participants

Reaction Steps

1-acetyl-4-[(piperidin-4-yloxy)methyl]benzoic acid (Preparation 102, 20 g, 72 mmol), aqueous sodium hydroxide solution (5 M, 75 ml), and methanol (75 ml) were heated to 100° C. for 4 h, and then evaporated to give a thick suspension. The crystals were filtered off, dissolved in water and the pH adjusted to 1 with hydrochloric acid (2 M, 200 ml) at 0° C. The cloudy solution was evaporated to dryness and the white solid recrystallised from isopropyl alcohol to give the title compound (15.2 g, 90%).

Provenance & Evidence