反应详情

Phenylmethyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate camphor sulphonic acid salt (Preparation 121, 8.3 g, 18.9 mmol) was dissolved in ethanol (600 ml) and palladium on carbon (10%, 0.8 g) was added at room temperature under nitrogen. The reaction mixture was hydrogenated at room temperature at 30 psi for 3 h. The catalyst was removed by filtration and the filtrate was concentrated to give the title compound (6.6 g, 100%).

1. customThe catalyst was removed by filtration
2. concentrationthe filtrate was concentrated