2-Ethyl-4-nitro-1,3-benzoxazole → 2-Ethyl-1,3-benzoxazol-4-amine

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Reaction Steps

2-ethyl-4-nitro-1,3-benzoxazole is hydrogenated under a pressure of 8 bars in the presence of 10% palladium on carbon (0.01 eq.) using methanol as a solvent. The catalyst is separated by filtration and the methanol is eliminated under reduced pressure. The residue is taken up in ethyl ether in order to produce a pale violet solid which is collected by filtration and dried. Melting point: 46° C.

Provenance & Evidence