tert-Butanol → HCID 57425849, compound

Participants

Reaction Steps

In a 10 mL flask with 3-benzyloxymethyl-1-cyclobutene (0.1 g, 0.57 mmol) inside, 0.72 mL tBuOMe, 1.54 mL tBuOH and 0.54 mL H2O were added to give two layers. Then NMO (50% wt sol. in H2O, 0.36 mL, 1.71 mmol) and OsO4 (0.07 mL, 0.06 mmol) were added drop by drop successively to give a light brown solution. This was left stirring at room temperature. After 3 hr, the solution was diluted with H2O and extracted with EtOAc three times. The organic layer was washed with brine once, dried over MgSO4 and concentrated. The crude product was purified by silica gel flash chromatography (Hexane:EtOAc=3:1 to Hexane: EtOAc=1:1) to give 27.4 mg (23%) the desired product. 1H NMR (CDCl3, 300 MHz): δ 1.70-1.92 (m, 2H), 2.46-2.75 (m, 1H), 3.02-3.2 (m, 1H), 3.2-3.34 (m, 1H), 3.4-3.6 (m, 2H), 3.90-4.10 (m, 1H), 4.2-4.4 (m, 1H), 4.4-4.6 (s, 2H), 7.21-7.50 (m, 5H). 13C NMR (CDCl3, 100 MHz): δ 28.08, 43.45, 68.32, 70.19, 71.41, 73.28, 127.83, 128.61, 138.56. IR (neat) νmax 3376, 2937, 2856, 1453, 1098, 738, 698.

Provenance & Evidence