Tetrabutylammonium Fluoride → HCID 178508640, compound

Participants

Reaction Steps

In a 25 mL flask with 9-[cis-3-(triisopropyl-siloxyethyl)cyclobutyl]adenine (0.07 g, 0.18 mmol) inside, dry THF 1.5 mL was added to give a totally clear light-yellow solution. This was treated with TBAF (1.0 M in THF, 0.36 mL, 0.36 mmol) at room temperature. After 1 hr, the solvent was removed and the crude product was directly applied to the silica gel flash chromatography (CH2Cl2 to CH2Cl2: MeOH=5:1) to give 0.04 g (90%) the desired product. MS (FAB): expected for C11H15N5O (M+H)+ 234.27. Found 234.13482.

Provenance & Evidence