Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclooctanol | HCID 12766 | — |
| Reactant | 2-Isocyanatoethyl methacrylate | HCID 35409 | — |
| Catalyst | Di-n-butyldilauryltin | HCID 9809426 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57567227 | HCID 57567227 | 80% |
Reaction Steps
A mixture of cyclooctanol (3.00 grams, 23 millimoles), 2-isocyanatoethyl methacrylate (3.63 grams, 23 millimoles), methylene chloride (10 milliliters), and one drop of dibutyltin dilaurate were stirred at 50° C. for three hours. The solvent was then removed under reduced pressure and the crude product was purified by column chromatography over silica gel using a mixture of ethyl acetate/hexane (20/80). The product was isolated as an oil (5.20 grams, 80% yield). Purity and structure verification of Comparative Example C5 were confirmed by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07495054B2 |
|---|
| Source dataset | uspto-grants-2009_02 |
|---|
| ORD ID | ord-85a36af5840c472dab0e8000ae5633f0 |
|---|
| Source note | uspto-grants-2009_02 |
|---|
