Bromine → 2-Bromo-2-(2-boc-amino-4-pyridyl)-1-(4-methoxyphenyl)ethanone hydrocbromide

Participants

Reaction Steps

To a solution of 2-(2-tert-butoxycarbonylamino-4-pyridyl)-1-(4-methoxyphenyl)ethanone (0.36 g, 1.1 mmol) in acetic acid (5 mL) was added bromine (0.058 mL, 1.1 mmol), and the mixture was stirred for 1 hour at room temperature. The reaction mixture was concentrated, and the residue was washed with isopropyl ether to obtain a title compound (0.44 g, yield 82%).

Provenance & Evidence