Bromine → HCID 11696686, compound

HRID 1727347Notes

Reaction equation

HRID 1727347 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:8](=[O:17])[CH2:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[CH:11]=2)[CH:5]=[CH:6][CH:7]=1.[Br:18]Br>C(O)(=O)C>[BrH:18].[Br:18][CH:9]([C:10]1[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[CH:11]=1)[C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[CH:3]=1)=[O:17]

Participants

4

Reactant 2

HCID 24408BromineHCID 116586421-(3-METHYLPHENYL)-2-(2-METHYL-4-PYRIDYL)ETHANONE

Product 1

HCID 11696686HCID 11696686, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
70 °C

Procedure

1-(3-methylphenyl)-2-(2-methyl-4-pyridyl)ethanone (150 g) was dissolved in acetic acid (450 mL), bromine (34.3 mL) was added to this, and the mixture was stirred for 3 hours at 70° C. The reaction solution was cooled by ice water, and the deposited crystal was filtrated off. The crystal was washed with ethyl acetate to obtain a title compound (168 g, yield 66%).

Workup

  1. filtrationthe deposited crystal was filtrated off
  2. washThe crystal was washed with ethyl acetate

Sources & evidence

ORD record
ord-0dcce69f607642eebd1a9fb19f774751
Source dataset
uspto-grants-2009_02
Patent number
US07495018B2

Reaction notes

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