1-Phenylpiperazine → ETHYL (4-PHENYL-1-PIPERAZINYL)CARBOTHIOYLCARBAMATE

Participants

Reaction Steps

To a solution of ethyl isothiocyanatoformate (8.1 g, 62 mmol) in acetone (30 mL) was added 1-phenylpiperazine (10 g, 62 mmol), and the mixture was heated to reflux for 1 hour. The reaction mixture was concentrated, and the crude crystal was recrystallized from ethyl acetate to obtain a title compound (13 g, yield 73%).

Provenance & Evidence