Hydrochloric Acid → 4-PHENYL-1-PIPERAZINECARBOTHIOAMIDE

Participants

Reaction Conditions

Reaction Steps

Ethyl (4-phenyl-1-piperazinyl)carbothioylcarbamate (13 g, 44 mmol) was added to conc. hydrochloric acid (44 mL), and the mixture was stirred for 2 hours at 80° C. The reaction mixture was made basic with an 8N-aqueous sodium hydroxide solution, and the crystal was collected by filtration. The crystal was washed with water, and dried to obtain a title compound (6.1 g, yield 63%).

Provenance & Evidence