反应详情

To a solution of 4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridylamine (0.80 g, 2.7 mmol) in tetrahydrofuran (10 mL) were added cyclohexanecarbonyl chloride (0.40 mL, 3.0 mmol) and triethylamine (0.39 mL, 2.8 mmol) sequentially, and the mixture was stirred for 1 hour at room temperature. To the reaction mixture was added an aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The extracts were washed with an aqueous sodium hydrogen carbonate solution, then, dried and concentrated. The residue was purified by silica gel column chromatography (hexane-ethyl acetate=20:1 to 4:1) to obtain a crystal. This crystal was washed with hexane to obtain a title compound (0.83 g, yield 75%).

1. extractionextracted with ethyl acetate
2. washThe extracts were washed with an aqueous sodium hydrogen carbonate solution
3. customdried
4. concentrationconcentrated
5. customThe residue was purified by silica gel column chromatography (hexane-ethyl acetate=20:1 to 4:1)
6. customto obtain a crystal
7. washThis crystal was washed with hexane