Potassium Hydroxide → 916214-57-8

HRID 1727448Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1727448
[OH:1][C:2]1[CH:10]=[CH:9][C:8]([NH:11][CH2:12][C:13]2[C:18]([F:19])=[C:17]([F:20])[C:16]([C:21]([F:24])([F:23])[F:22])=[C:15]([F:25])[C:14]=2[F:26])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH-].[K+:28]>C(O)C>[OH:1][C:2]1[CH:10]=[CH:9][C:8]([NH:11][CH2:12][C:13]2[C:14]([F:26])=[C:15]([F:25])[C:16]([C:21]([F:24])([F:23])[F:22])=[C:17]([F:20])[C:18]=2[F:19])=[CH:7][C:3]=1[C:4]([O-:6])=[O:5].[K+:28]

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 99519552-Hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)benzoic acid

Produkt 1

HCID 23684338916214-57-8Ausbeute 91,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)benzoic acid (10 g, 0.261 mole), as prepared in Example 3, was added to anhydrous ethanol (500 ml) and then the temperature was allowed to rise to 50° C. for complete dissolution. The resulting solution was cooled to 10° C. The pH of the solution was adjusted to 6.8-7.0 using a separately prepared solution of 85%-potassium hydroxide (17.22 g, 0.261 mole) and anhydrous ethanol (30 ml). The reaction mixture was stirred for 2 hours at room temperature and then the precipitated crystals were filtered and dried to give 100.8 g (0.239 mole, 91.7% yield) of potassium 2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)benzoate as the desired compound.

Aufarbeitung

  1. dissolutionto rise to 50° C. for complete dissolution
  2. filtrationthe precipitated crystals were filtered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-8a2a0d9806c141c8a434d4b874cb3397
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07495126B2

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