1-Tosyl-1H-pyrrolo(2,3-B)pyridine-4-boronic acid pinacol ester → 4-[2-methyl-4-(4-nitrophenyl)-1,3-thiazol-5-yl]-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine

HRID 1727771노트

반응식

HRID 1727771 반응식
Br[C:2]1[S:6][C:5]([CH3:7])=[N:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1.[CH3:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([N:27]2[C:31]3=[N:32][CH:33]=[CH:34][C:35](B4OC(C)(C)C(C)(C)O4)=[C:30]3[CH:29]=[CH:28]2)(=[O:26])=[O:25])=[CH:20][CH:19]=1>>[CH3:7][C:5]1[S:6][C:2]([C:35]2[CH:34]=[CH:33][N:32]=[C:31]3[N:27]([S:24]([C:21]4[CH:22]=[CH:23][C:18]([CH3:17])=[CH:19][CH:20]=4)(=[O:25])=[O:26])[CH:28]=[CH:29][C:30]=23)=[C:3]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=2)[N:4]=1

참가 물질

3

반응물 2

HCID 497589261-Tosyl-1H-pyrrolo(2,3-B)pyridine-4-boronic acid pinacol esterHCID 689981005-Bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole

생성물 1

HCID 690011984-[2-methyl-4-(4-nitrophenyl)-1,3-thiazol-5-yl]-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine

실험 절차

Following the procedure described for Intermediate 6 with 5-bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole and [(4-methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine provided title compound. ESMS [M+H]+: 491.2

출처 및 근거

ORD 기록
ord-61180d0bef2c481ca801be2095e68763
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07495102B2

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