反应详情

(4-Tert-butylphenyl)-{4-[6-methoxy-7-(4-piperidinylmethoxy)-4-quinolyloxy]phenyl}amine (150 mg) was dissolved in N,N-dimethylformamide (3 ml) to prepare a solution. Potassium carbonate (300 mg) and 1-bromopropane (0.15 ml) were then added to the solution, and the mixture was stirred at room temperature for 4 hr. Water and ethyl acetate were added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine and was dried over sodium sulfate. The solvent was removed by evaporation under the reduced pressure, and the residue was purified by thin-layer chromatography on silica gel using chloroform/acetone for development to give the title compound (12 mg, yield 7%).

1. customto prepare a solution
2. extractionthe mixture was extracted with ethyl acetate
3. washThe extract was washed with saturated brine
4. dry with materialwas dried over sodium sulfate
5. customThe solvent was removed by evaporation under the reduced pressure
6. customthe residue was purified by thin-layer chromatography on silica gel