1-Bromo-2-Chloroethane → HCID 57567594, compound

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Reaction Steps

A crude product of 1-(3,3-dimethyl-butyl)-3-[2-fluoro-4-(7-hydroxy-6-methoxy-quinolin-4-yloxy)-phenyl]-urea was dissolved in dimethylformamide (100 ml) to prepare a solution. Potassium carbonate (18 g) and 1-bromo-2-chloroethane (11 g) were added to the solution, and the mixture was stirred at room temperature for 20 hr. The mixture was extracted with ethyl acetate, was then washed with saturated brine, and was dried over anhydrous sodium sulfate. The solvent was removed by evaporation under the reduced pressure. The residue was washed with a mixed solvent of n-hexane: ethyl acetate (2:1) and was then collected by filtration to give 1-{4-[7-(2-chloroethoxy)-6-methoxy-quinolin-4-yloxy]-2-fluorophenyl}-3-(3,3-dimethyl-butyl)urea (7.7 g, yield 74%).

Provenance & Evidence