Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-Chlorobenzaldehyde | HCID 11477 | — |
| Reactant | 2-Cyanoethyl 3-aminocrotonate | HCID 13671410 | — |
| Reactant | Phenylmethyl 4-(2-chloroethoxy)-3-oxobutanoate | HCID 22570154 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 69074752 | HCID 69074752 | — |
Reaction Steps
500 mg (1.90 mmol) of 4-(2-chloroethoxy) acetoacetic acid benzyl ester, 260 mg (1.90 mmol) of 3-chlorobenzaldehyde, acetic acid and piperidine were heated and stirred at room temperature for 24 hours in 3 ml of 2-propanol. 280 mg (1.90 mmol) of 3-aminocrotonate 2-cyanoethyl ester was added and further heated and stirred at 50° C. for 48 hours. 2-propanol was evaporated under reduced pressure. The residue was purified by the silica gel chromatography (hexane/ethyl acetate=1/1) to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07494989B2 |
|---|
| Source dataset | uspto-grants-2009_02 |
|---|
| ORD ID | ord-eda29b8a8bf94065acea015cd471b7c9 |
|---|
| Source note | uspto-grants-2009_02 |
|---|
