反应详情

1.23 g (2.90 mmol) of 4-(2-cyclohexylethoxy)-3-oxobutanoic acid 3,3-diphenylpropyl ester, 0.33 ml (2.91 mmol) of 3-chlorobenzaldehyde, 0.05 ml (0.51 mmol) of piperidine and catalytic amount of p-toluenesulfonic acid were refluxed in 20 ml of benzene removing water for 1.5 hours. After adding ethyl acetate, the organic layer was washed with 1 N hydrochloric acid and saturated aqueous sodium hydrogencarbonate solution, and dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain the title compound.

1. customremoving water for 1.5 hours
2. additionAfter adding ethyl acetate
3. washthe organic layer was washed with 1 N hydrochloric acid and saturated aqueous sodium hydrogencarbonate solution
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure