Acetone → HCID 10145745, compound

HRID 1727945Notes

Reaction equation

HRID 1727945 reaction equation
CC(C)=O.[CH:5]1[C:15]2[CH:14]=[CH:13][C:12]3[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=3[C:10](=[C:20]3[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][CH2:28][O:29][C:30]([C:32]4[CH:37]([C:38]5[CH:43]=[CH:42][CH:41]=[C:40]([Cl:44])[CH:39]=5)[C:36]([C:45]([OH:47])=[O:46])=[C:35]([CH3:48])[NH:34][C:33]=4[CH3:49])=[O:31])[CH2:22][CH2:21]3)[C:9]=2[CH:8]=[CH:7][CH:6]=1.[N+]([O-])([O-])=O.[NH4+].[Ce]>O>[Cl:44][C:40]1[CH:39]=[C:38]([C:37]2[C:36]([C:45]([OH:47])=[O:46])=[C:35]([CH3:48])[N:34]=[C:33]([CH3:49])[C:32]=2[C:30]([O:29][CH2:28][CH2:27][CH2:26][N:23]2[CH2:22][CH2:21][C:20](=[C:10]3[C:9]4[CH:8]=[CH:7][CH:6]=[CH:5][C:15]=4[CH:14]=[CH:13][C:12]4[CH:16]=[CH:17][CH:18]=[CH:19][C:11]3=4)[CH2:25][CH2:24]2)=[O:31])[CH:43]=[CH:42][CH:41]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 57418452Ammonium cerium-nitrateHCID 86590787HCID 86590787, compound

Product 1

HCID 10145745HCID 10145745, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 ml of acetone was added to 132 mg (0.21 mmol) of 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid mono (3-(4-(5H-dibenzo[a,d] cyclohepten-5-ylidene) piperidine-1-yl) propan-1-yl) ester. 233 mg (0.43 mmol) of cerium ammonium nitrate suspended in 5 ml of water was added and stirred at room temperature for 2 hours. After acetone was evaporated under reduced pressure, ethyl acetate was added and precipitates were taken by the filtration and dried under reduced pressure to obtain the title compound.

Workup

  1. additionwas added
  2. customAfter acetone was evaporated under reduced pressure, ethyl acetate
  3. additionwas added
  4. customprecipitates
  5. filtrationwere taken by the filtration
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-30c6dfce75c74c8b8df8f8505f63bb53
Source dataset
uspto-grants-2009_02
Patent number
US07494989B2

Reaction notes

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